C. Castro

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

Piggybacking functionalized DNA nanostructures into live cell nuclei

This study demonstrates the delivery of DNA origami nanorods into live cell nuclei using an antibody against RNA Polymerase II, showing structural integrity and sub-diffusive motion within the nucleus.

Construction and reconfiguration of dynamic DNA origami assemblies with coiled-coil patches and patterns

This paper constructs dynamic DNA origami assemblies using coiled-coil peptides to create reconfigurable structures with tunable mechanical properties.

Cooperative control of a DNA origami force sensor

The paper introduces a DNA origami-based force sensor called NanoDyn that can be tuned to detect forces in the picoNewton range and demonstrates its reversibility and adjustability.

Mechanism of DNA origami folding elucidated by mesoscopic simulations

This paper develops a mesoscopic simulation model to study DNA origami folding, revealing hierarchical processes and kinetic differences between small and large structures.

Accelerating the Characterization of Dynamic DNA Origami Devices with Deep Neural Networks

This paper develops a deep learning pipeline to rapidly characterize dynamic DNA nanodevices by detecting particles and estimating their conformation from images.

Versatile Computer Aided Design of Freeform DNA Nanostructures and Assemblies

The paper introduces MagicDNA 2.0, a tool for automated design of freeform 3D DNA nanostructures, validated through experimental fabrication of complex geometries.

Long-term survival and induction of operational tolerance to murine islet allografts through the co-transplantation of cyclosporine A eluting microparticles

This study shows that localized cyclosporine A delivery via microparticles combined with CTLA4-Ig reduces islet allograft rejection and induces operational tolerance in mice.

DNA-caged Nanoparticles via Electrostatic Self-Assembly

This paper introduces an electrostatic DNA caging method for nanoparticle modification, demonstrating its versatility in biosensing and material applications.

Thermally Reversible Pattern Formation in Arrays of Molecular Rotors

This study uses Monte Carlo simulations and experimental DNA origami rotors to show thermally reversible pattern formation in molecular rotor arrays, demonstrating order-disorder transitions and potential applications in nanomaterials.

Multiplexed Detection of Molecular Interactions with DNA Origami Engineered Cells in 3-D Collagen Matrices

The paper develops a DNA origami-based biosensor to monitor live cell interactions with biomolecules in 3-D microfluidic environments.

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

Single amino acid-promoted reactions link a non-enzymatic chemical network to the early evolution of enzymatic pentose phosphate pathway

This paper shows how single amino acids can enhance non-enzymatic reactions similar to the pentose phosphate pathway, suggesting a stepwise evolution from environmental chemical networks to enzymatic metabolism.

Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

Statistical optimization of culture conditions to improve cell density of Komagataeibacter medellinensis NBRC 3288: the first step towards to optimize bacterial cellulose production

This paper optimizes culture conditions for Komagataeibacter medellinensis to increase cell density and reduce production costs.