J. Parreno

Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes

This study investigates how TPM3.1 and CDC42 regulate F-actin stress fibers and dedifferentiation in passaged chondrocytes, showing their roles in maintaining the dedifferentiated phenotype.

Destabilization of F-actin by Mechanical Stress Deprivation or Tpm3.1 Inhibition Promotes a Pathological Phenotype in Tendon Cells

This study shows that F-actin destabilization by mechanical stress deprivation or Tpm3.1 inhibition in tendon cells leads to pathological gene expression changes associated with tendinosis.

Microstructural determinants of lens stiffness in rat versus guinea pig lenses

The paper investigates the biomechanical stiffness differences between rat and guinea pig lenses, finding that nuclear size, not overall lens size, is a key determinant of stiffness.

Tpm3.1 association with actin stress fibers is required for lens epithelial to mesenchymal transition

This study shows that Tpm3.1 is required for actin stress fiber formation during lens epithelial to mesenchymal transition, and inhibiting Tpm3.1 reduces EMT markers.

The effects of mechanical strain on mouse eye lens capsule and cellular microstructure

This study examines how mechanical strain affects the structure of mouse eye lenses, finding reversible and irreversible changes in microstructure depending on strain magnitude.