Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence
A. Y. Park, M. Leney-Greene, M. Lynberg, X. Xu, L. Zheng, Y. Zhang, H. Matthews, B. Chao, A. Morawski, P. Jiang, J. Aluri, E. K. Aydine, A. Kiykim, J. Pascall, I. Barlan, , M. J. Lenardo
This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.
bioRxiv · Feb 22, 2021 · PreprintImmunology