P. Jiang

Modulating Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity

This study shows that altering the microenvironment of mesenchymal stromal cells changes exosome RNA content and improves ligament healing in rats.

Molecular stratification of human fetal vaginal epithelium by spatial transcriptome analysis

This study uses spatial transcriptomics to classify human fetal vaginal epithelium into four zones, identifying distinct gene expression patterns and potential differentiation trajectories.

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's Disease

The paper studies sleep-wake abnormalities in a new PD mouse model and finds they mirror human PD symptoms, suggesting potential for understanding and treating sleep disruptions in PD.

Multi-Omics Analysis Of Antiviral Interactions Of Elizabethkingia anophelis And Zika Virus

This study investigates the antiviral interactions between Elizabethkingia anophelis and Zika virus using multi-omics analysis, revealing attenuated viral replication and altered metabolic pathways.

Identification of potential distribution area for the sweet cherry (Prunus avium) by the MaxEnt model

The paper models the potential distribution of sweet cherry trees in China using the MaxEnt model, identifying key climate factors and suitable regions for cultivation.

Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

Optimal transport for mapping senescent cells in spatial transcriptomics

The paper develops scDOT, a method combining spatial transcriptomics and single-cell RNA-seq with optimal transport to improve spatial mapping of senescent cells and identify novel genes involved in cell-cell interactions.

The E2 SUMO-conjugating enzyme UBE2I coordinates the oocyte and zygotic transcriptional programs

This study shows that oocyte-specific deletion of Ube2i leads to meiotic arrest, defective spindles, and premature zygotic transcriptional activation in mice.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

Effect of GDF15 on acetaminophen (APAP)-induced liver injury in mice

This study investigates the role of GDF15 in APAP-induced liver injury in mice, finding no significant ameliorative effect from overexpression or supplementation of GDF15.

The bladder microbiome, metabolome, cytokines, and phenotypes in patients with systemic lupus erythematosus

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.

Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion.

This study shows Salmonella chitinases enhance intestinal invasion by modulating host glycans, with chitinase-deficient strains showing reduced invasion and delayed dissemination.

The effect of mutational robustness on the evolvability of multicellular organisms

This study investigates how mutational robustness affects evolvability in multicellular organisms using a Boolean model, finding that high robustness is favored in stable environments but lower robustness is advantageous after environmental change.

Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

The paper uses a modified fluctuation assay to identify natural mutator phenotypes in S. cerevisiae strains, revealing a 10-fold mutation rate range and distinctive mutation spectra in two strains.

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

This paper introduces GETMap, a method to determine tissue origin of plasma DNA carrying genetic variants, validated across prenatal testing, transplantation, and oncology scenarios.

Genetic and Immunological Evidence for Microbial Transfer Between the International Space Station and an Astronaut

The paper tracks microbial transfer between an astronaut and the ISS environment, identifies specific taxa, and shows immune system adaptation.

Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

TRIM21 and PHLDA3 Negatively Regulate the Cross-Talk between the PI3K/AKT Pathway and PPP Metabolism

This study shows TRIM21 and PHLDA3 regulate cross-talk between PI3K/AKT signaling and PPP metabolism, with implications for cancer therapy.

Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.

MITA couples with PI3K to regulate actin reorganization during BCR activation

This study shows MITA regulates BCR signaling through actin reorganization via the PI3K pathway, affecting B cell differentiation and autoimmune disease.