Author

H. Matthews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Bioengineering· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3 Assay:clinical cohort / trial· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. J. Lenardo· 2 shared P. Claes· 2 shared Y. Zhang· 2 shared A. A. Zaidi· 1 shared A. Alazami· 1 shared A. E. Ward· 1 shared A. Gutnov· 1 shared A. Kiykim· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

M. J. Lenardo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Connecting Thiamine Availability to the Microbial Community Composition in Chinook Salmon Spawning Habitats of the Sacramento River Basin

C. P. Suffridge, K. C. Shannon, H. Matthews, R. Johnson, C. Jeffres, N. Mantua, A. E. Ward, E. Holmes, J. Kindopp, M. Aidoo, F. Colwell

The paper investigates thiamine and its metabolites (dTRCs) in Sacramento River spawning habitats, linking microbial communities to thiamine availability for Chinook salmon.

bioRxiv · Aug 22, 2023Microbiology

Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation

S. Ganguli, T. Wyatt, T. Meyer, B. Baum, H. Matthews

This study shows oncogenic Ras-ERK signalling alters cell division orientation by affecting actomyosin contractility and cell-substrate interactions during mitotic rounding and respreading.

bioRxiv · Jan 12, 2023Cell Biology

A 3D Clinical Face Phenotype Space of Genetic Syndromes using a Triplet-Based Singular Geometric Autoencoder

S. S. Mahdi, E. Caldeira, H. Matthews, M. Vanneste, N. Nauwelaers, M. Yuan, S. Gong, G. Bouritsas, G. S. Baynam, P. Hammond, R. Spritz, O. D. Klein, M. Bronstein, B. D. Hallgrimsson, H. Peeters, P. Claes

This paper develops a triplet-based geometric autoencoder to create a clinical face phenotypic space for syndrome diagnosis, showing it can classify syndromes, generalize to new ones, and preserve genetic disease relationships.

bioRxiv · Dec 27, 2022Bioengineering

Dynamics of DNA replication during male gametogenesis in the malaria parasite Plasmodium falciparum

H. Matthews, J. McDonald, F. I. G. Totanes, C. J. Merrick

The paper tracks DNA replication dynamics during male gametogenesis in Plasmodium falciparum, revealing unique features like no pre-gametogenesis replication, absence of karyokinesis between replication rounds, uncoupled cytokinesis, and distinct single-molecule replication dynamics.

bioRxiv · Dec 18, 2021Microbiology

Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

A. Y. Park, M. Leney-Greene, M. Lynberg, X. Xu, L. Zheng, Y. Zhang, H. Matthews, B. Chao, A. Morawski, P. Jiang, J. Aluri, E. K. Aydine, A. Kiykim, J. Pascall, I. Barlan, , M. J. Lenardo

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

bioRxiv · Feb 22, 2021 · PreprintImmunology

Lead optimisation of dehydroemetine for repositioned use in malaria

P. Panwar, K. Burusco, M. Abubaker, H. Matthews, A. Gutnov, E. Fernandez-Alvaro, R. Bryce, J. Wilkinson, N. J. Nirmalan

This paper optimizes 2,3-dehydroemetine for repositioned use in malaria by showing its potency against P. falciparum and lack of cardiotoxicity.

bioRxiv · Feb 1, 2019Microbiology

MeshMonk: Open-source large-scale intensive 3D phenotyping

J. D. White, A. Ortega-Castrillon, H. Matthews, A. A. Zaidi, O. Ekrami, J. Snyders, Y. Fan, A. Penington, S. Van Dongen, M. D. Shriver, P. Claes

MeshMonk provides a tool for fast and accurate 3D phenotyping of images, validated with facial images and showing high precision in landmark placement.

bioRxiv · Jan 7, 2019Evolutionary Biology

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

Z. Zhang, F. Gothe, P. Pennamen, J. James, D. MacDonald, C. P. Mata, Y. Modis, M. Acres, W. Haller, C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, A. Alazami, Y. Zhang, , M. J. Lenardo

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

bioRxiv · Nov 26, 2018Immunology