Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives
L. Zou, P. Spanogiannopoulos, H.-C. Chien, L. M. Pieper, W. Cai, N. Khuri, J. Pottel, B. Vora, Z. Ni, E. Tsakalozou, W. Zhang, B. K. Shoichet, K. M. Giacomini, P. J. Turnbaugh
The paper identifies food and drug additives that inhibit intestinal drug transporters and shows gut bacteria can inactivate these additives, reducing their inhibitory effect.
bioRxiv · Oct 28, 2019Pharmacology & Toxicology