P. J. Turnbaugh

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

The paper introduces EASi-seq, a method for single-cell sequencing of microbes using a commercial platform, enabling detailed microbiome atlases and improved bioinformatic analysis.

This study shows that mild SARS-CoV-2 infection causes long-term gut microbiota instability in both humans and mice, with Omicron variant also disrupting microbial communities despite causing milder symptoms.

This paper shows that the FNR regulator in E. coli is essential for azo bond degradation in the gut, influenced by oxygen and cysteine levels.

The gut bacterium Eggerthella lenta secretes inhibitors of P-glycoprotein ATPase activity, accelerating drug absorption.

This study identifies the metabolic niche of Eggerthella lenta in the human gut by combining experimental and computational approaches, revealing its use of acetate and arginine catabolism.

The paper describes synthetic glycans that alter gut microbiome structure and reduce colitis in mice by selectively affecting bacterial growth and metabolism.

This study uses phage-delivered CRISPR-Cas9 to deplete specific E. coli strains and induce genomic deletions in the gut microbiome of mice.

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

The paper compares gut microbiomes of East Asian and White individuals in the same geographic area, finding ethnic differences linked to metabolic health and independent of diet.

The paper identifies food and drug additives that inhibit intestinal drug transporters and shows gut bacteria can inactivate these additives, reducing their inhibitory effect.

The paper identifies a molybdenum-dependent enzyme in gut bacteria that dehydroxylates catechols, revealing its role in microbial metabolism and broader ecological relevance.

This study shows that methotrexate, a non-antibiotic drug, alters the human gut microbiota, favoring Firmicutes over Bacteroidetes, which correlates with improved drug response in rheumatoid arthritis patients.

This study identifies reproducible gut microbiome changes induced by a high-fat diet in mice and shows that a machine learning model can predict dietary intake in mice and humans.

The paper identifies large phage (Lak phage) in gut microbiomes that infect Prevotella and are widespread, especially in developing-world individuals.