P. Spanogiannopoulos

The global anaerobic metabolism regulator fnr is necessary for the degradation of food dyes and drugs by Escherichia coli

This paper shows that the FNR regulator in E. coli is essential for azo bond degradation in the gut, influenced by oxygen and cysteine levels.

A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy

The paper shows that a conserved enzyme in gut bacteria inactivates anticancer drugs, reducing their efficacy in mice and highlighting microbial contributions to drug metabolism.

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

This study uses phage-delivered CRISPR-Cas9 to deplete specific E. coli strains and induce genomic deletions in the gut microbiome of mice.

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

The paper identifies food and drug additives that inhibit intestinal drug transporters and shows gut bacteria can inactivate these additives, reducing their inhibitory effect.

The Genetic Basis for the Cooperative Bioactivation of Plant Lignans by a Human Gut Bacterial Consortium

The paper identifies the genetic basis for the cooperative bioactivation of plant lignans by a human gut bacterial consortium, revealing a complete metabolic pathway in most human gut microbiomes.