J. R. Blundell

This study develops a statistical framework to identify TCR clonotypes under immune selection in time series data and finds that dynamic clusters of clonotypes suggest shared immunogenic stimuli despite diverse sequence features.

The paper estimates genome-wide driver mutation rates in healthy tissues using synonymous passenger mutations and finds many driver mutations occur outside of known cancer genes in blood but not in oesophagus.

This study investigates genetic diversity dynamics in clonally evolving populations, finding predictable early increases followed by a diversity crash due to highly-fit double mutants.