Cell BiologybioRxiv
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism
A. T. Byrd, L. Marmorale, V. Addison…·J. R. Buchan
This study identifies ESCRT and Rsp5/NEDD4 as regulators of TDP-43 clearance via endolysosomal pathways, showing their role in reducing TDP-43 toxicity in ALS models.
DOI 10.1083/jcb.202212064