B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments.
S. Hernandez-Perez, M. Vainio, E. Kuokkanen, V. Sustar, P. Petrov, S. Forsten, V. Paavola, J. Rajala, L. Awoniyi, A. Sarapulov, H. Vihinen, E. Jokitalo, A. Bruckbauer, P. Mattila
This study identifies specialized early peripheral acidic vesicles (eMIIC) in B cells that facilitate rapid antigen processing and MHCII peptide loading for immune response.
bioRxiv · Oct 30, 2019Immunology