S. Hernandez-Perez

This study isolates and profiles immune synapses from primary mouse B cells to identify proteins involved in early activation by surface-bound antigens, revealing novel components and pathways.

This study shows that Rab8a deficiency in B cells increases antibody responses and class-switch recombination by altering signaling pathways.

This study uses proximity proteomics to identify dynamic protein changes and SUMOylation events in BCR activation, revealing new roles in signaling pathways.

This study shows that MIM/MTSS1 regulates B cell receptor signaling, metabolic activity, and T cell-independent immune responses, with implications for cancer biology.

This study identifies specialized early peripheral acidic vesicles (eMIIC) in B cells that facilitate rapid antigen processing and MHCII peptide loading for immune response.