J. Rog

Metabotropic purinergic receptor profiles and calcium signalling in primary mice myoblasts differ depending on their muscle origin and are altered in cells with mutated dystrophin gene (mdx mice)

The paper investigates metabotropic purinergic receptor profiles and calcium signaling in primary myoblasts from different muscles of normal and mdx mice, finding differences in P2Y receptor expression and calcium signaling proteins between muscle origins and mdx mutations.

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

This study shows that loss of full-length dystrophin in myoblasts causes cell-autonomous defects in gene expression, proliferation, chemotaxis, and differentiation, contributing to muscle regeneration failure in Duchenne muscular dystrophy.