Cancer BiologybioRxiv
Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor
M. V. Ortiz, S. Ahmed, M. Burns…·A. Kentsis
This study identifies prohibitin as a urine biomarker for Wilms tumor relapse and shows it promotes chemotherapy resistance by disrupting mitochondrial apoptosis.
DOI 10.1172/jci.insight.127098