Matrix Softening Controls Stretch-Induced Cellular Memory and Fibroblast Activation
Y. Hong, X. Peng, H. Yu, M. Jafari, D. Shakiba, Y. Huang, C. Qu, E. Melika, A. Tawadros, A. Mujahid, J. Sandler, K. Pryse, J. Sacks, E. Elson, G. Genin, F. Alisafaei
This study shows that matrix softening influences stretch-induced cellular memory and fibroblast activation, with a model predicting activation levels based on ECM properties.
bioRxiv · Oct 12, 2022 · PreprintBiophysics