BBB-on-a-chip with Integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease
S. F. Palma Florez, A. Lopez-Canosa, F. Morales-Zavala, O. Castano, M. J. Kogan, J. Samitier, A. Lagunas, M. Mir
This paper develops a BBB-on-a-chip platform with integrated micro-TEER to evaluate the permeability of GNR-PEG-Ang2/D1 nanotherapeutics for Alzheimer's disease, showing its ability to cross the BBB and affect tight junctions.
bioRxiv · Sep 5, 2022 · PreprintBioengineering