J. Mora

Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer

This study tracks T cell dynamics in a pediatric cancer patient post-ICI therapy to identify tumor-reactive TCRs for personalized TCR-T cell therapy.

KDM6 demethylases mediate EWSR1-FLI1-driven oncogenic transformation in Ewing Sarcoma

This study identifies KDM6A and KDM6B as EWSR1-FLI1 cofactors in Ewing Sarcoma, showing distinct roles in enhancer activation and tumor growth.

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection

This study finds SARS-CoV-2 S1 protein in non-classical monocytes in PASC patients up to 15 months post-infection, but not full-length viral RNA.

High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern

This study demonstrates that therapeutic equine polyclonal antibodies effectively neutralize SARS-CoV-2 variants of concern.

HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

This study shows HDAC6 regulates EWSR1-FLI1 expression in Ewing sarcoma by modulating SP1 acetylation and promoter binding, with HDAC6 inhibition reducing oncogenic activity and enhancing treatment response.

Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning

The paper uses machine learning to predict and distinguish phases of COVID-19 severity and chronicity based on immune profiles from different patient groups.

Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance.

This study uses dynamic BH3 Profiling to identify BH3 mimetic combinations that enhance chemotherapy efficacy and prevent resistance in rhabdomyosarcoma.