BiochemistrybioRxiv
Beyond the seed: structural basis for supplementary mircoRNA targeting
J. Sheu-Gruttadauria, Y. Xiao, L. F. R. Gebert, I. J. MacRae
The paper reports the structure of Ago2 bound to a target RNA using both seed and supplementary regions, showing supplementary interactions significantly enhance target affinity.
DOI 10.15252/embj.2018101153