Author

J. Shing

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. J. Rauch· 1 shared E. Nogales· 1 shared F. Jiang· 1 shared J. A. Doudna· 1 shared J. Bondy-Denomy· 1 shared J. E. Corn· 1 shared J.-J. Liu· 1 shared N. L. Bray· 1 shared

Activity by Year

2017-2017 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

B. J. Rauch

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1 paper

Recent·Most cited

Disabling Cas9 by an anti-CRISPR DNA mimic

J. Shing, F. Jiang, J.-J. Liu, N. L. Bray, B. J. Rauch, S. H. Baik, E. Nogales, J. Bondy-Denomy, J. E. Corn, J. A. Doudna

This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.

bioRxiv · Apr 23, 2017Biochemistry