Author

B. J. Rauch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

E. Nogales· 2 shared F. Jiang· 2 shared J. A. Doudna· 2 shared J. Bondy-Denomy· 2 shared J.-J. Liu· 2 shared B. A. Osuna· 1 shared J. D. Berry· 1 shared J. E. Corn· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

E. Nogales

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2 papers

Recent·Most cited

BiochemistrybioRxivSep 3, 2018

Temperature-responsive competitive inhibition of CRISPR-Cas9

F. Jiang, J.-J. Liu, B. A. Osuna…·J. A. Doudna

This study shows AcrIIA2 and AcrIIA2b inhibit Cas9 DNA binding through structural occlusion, with temperature-dependent effects due to structural and environmental differences.

DOI 10.1016/j.molcel.2018.11.016

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiochemistrybioRxivApr 23, 2017

Disabling Cas9 by an anti-CRISPR DNA mimic

J. Shing, F. Jiang, J.-J. Liu…·J. A. Doudna

This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.

DOI 10.1126/sciadv.1701620

humanexperimental assay

𝕏 PostBluesky