Author

N. L. Bray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. J. Rauch· 1 shared E. Nogales· 1 shared F. Jiang· 1 shared J. A. Doudna· 1 shared J. Bondy-Denomy· 1 shared J. Corn· 1 shared J. E. Corn· 1 shared J. Shin· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

B. J. Rauch

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2 papers

Recent·Most cited

Controlled cycling and quiescence enables homology directed repair in engraftment-enriched adult hematopoietic stem and progenitor cells

J. Shin, S. K. Wyman, M. A. DeWitt, N. L. Bray, J. Vu, J. Corn

This study shows that quiescent hematopoietic stem and progenitor cells (HSPCs) predominantly use error-prone repair, while cycling cells use both error-prone and accurate repair, and presents a strategy to enhance homology-directed repair (HDR) by cycling HSPCs.

bioRxiv · Apr 13, 2018Cell Biology

Disabling Cas9 by an anti-CRISPR DNA mimic

J. Shing, F. Jiang, J.-J. Liu, N. L. Bray, B. J. Rauch, S. H. Baik, E. Nogales, J. Bondy-Denomy, J. E. Corn, J. A. Doudna

This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.

bioRxiv · Apr 23, 2017Biochemistry