F. Jiang

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

Identification of a distinct cluster of GDF15high macrophages exhibiting anti-inflammatory activities

The paper identifies a distinct cluster of GDF15high macrophages with anti-inflammatory properties using single-cell RNA sequencing and functional assays.

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

Cardiomyocyte-specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy

This study shows that loss of EPRS1 in cardiomyocytes causes dilated cardiomyopathy and heart failure, with altered protein homeostasis and metabolic pathways.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

Mn2+-Induced Structural Flexibility Enhances the Entire Catalytic Cycle and the Cleavage of Mismatches in Prokaryotic Argonaute Proteins

This study shows that Mn2+ enhances pAgo protein flexibility, improving catalytic efficiency and mismatch cleavage through structural changes.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay

This paper introduces a 3D spheroid-microvasculature-on-a-chip model to study tumor-endothelium mechanobiology interactions under controlled flow conditions.

Age and lead configuration matter: A comparative study of RF-induced heating of epicardial and endocardial electronic devices in adult and pediatric anthropomorphic phantoms in 1.5 T MR

This study compares RF-induced heating of cardiac implantable electronic devices in adult and pediatric phantoms with epicardial and endocardial leads, finding significant differences in heating based on age and lead configuration.

Mechanism of dual pharmacological correction and potentiation of human CFTR

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

Modifying the trajectory of epicardial leads can substantially reduce MRI-induced RF heating in pediatric patients with a cardiac implantable electronic device

This study shows that modifying epicardial lead trajectories can significantly reduce MRI-induced RF heating in pediatric patients with cardiac implants.

Time-varying Dynamic Network Model For Dynamic Resting State Functional Connectivity in fMRI and MEG imaging

This paper introduces a time-varying dynamic network model to analyze dynamic resting state functional connectivity in fMRI and MEG data, showing improved performance in capturing brain dynamics and detecting state transitions.

Streptococcus Pneumoniae Promotes Lung Tumorigenesis by Activating PI3K/AKT and NF-kB Pathways via Binding PspC to PAFR

This study shows Streptococcus pneumoniae promotes lung tumorigenesis by activating PI3K/AKT and NF-kB pathways through PspC-PAFR binding in lung cancer cells.

Cohesin mutation sensitizes cancer cells to anti-PD-1 therapy through endogenous retrovirus-mediated PD-L1 upregulation

This study shows cohesin mutations enhance cancer cell sensitivity to anti-PD-1 therapy by increasing PD-L1 through endogenous retrovirus activation.

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Dextran Sodium Sulfate-Induced Ulcerative Colitis

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia

This paper presents cryo-EM structures of myosin-15 bound to F-actin, revealing how mutations affect actin polymerization and stereocilia elongation.

A Systematic and Consistent Assay for High-throughput Characterization of Stalk Quality in Sugarcane by Near-infrared Spectroscopy

This study develops a high-throughput method using near-infrared spectroscopy to assess sugarcane stalk quality, achieving high prediction accuracy with RPD values up to 6.3.

Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation

This study designs perphenazine-cyclam conjugates that bind Aβ42 monomers, reducing toxic oligomers and fibrils, and inhibit amyloid formation even with pre-formed seeds.

Targeting KRAS-mutant stomach/colorectal tumours by disrupting the ERK2-p53 complex

This study identifies the ERK2-p53 complex as a therapeutic target in KRAS-mutant stomach/colorectal cancers, showing that disrupting it with MEK1/2 and ERK2 inhibitors induces apoptosis.

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 deafness

This study characterizes the ATPase mechanism of MYO15A, a motor protein involved in stereocilia development, and identifies its kinetic properties relevant to hearing loss.

Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

The paper reports the crystal structure of SARS-CoV-2 main protease bound to shikonin, revealing conformational changes and binding modes that could inform drug design.

MicroRNA-574 Regulates FAM210A Expression and Influences Pathological Cardiac Remodeling

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

Dissecting molecular regulatory mechanisms underlying noncoding susceptibility SNPs associated with 19 autoimmune diseases using multi-omics integrative analysis

This paper identifies functional noncoding SNPs and their molecular mechanisms for 19 autoimmune diseases using multi-omics data and prioritizes drug targets.

EPRS Regulates Proline-rich Pro-fibrotic Protein Synthesis during Cardiac Fibrosis

This study identifies EPRS as a key regulator of proline-rich pro-fibrotic gene translation in cardiac fibrosis, showing its role in promoting fibrosis and identifying potential therapeutic targets.

Red and black: A β-carotene-binding protein carrying a red pigment regulates body-color transition in locusts

This study identifies a β-carotene-binding protein that regulates body color transition in locusts by modulating red pigment accumulation.

Temperature-responsive competitive inhibition of CRISPR-Cas9

This study shows AcrIIA2 and AcrIIA2b inhibit Cas9 DNA binding through structural occlusion, with temperature-dependent effects due to structural and environmental differences.

Small-scale soil microbial community heterogeneity linked to landforms on King George Island, maritime Antarctica

The paper examines soil microbial community differences linked to landforms in Antarctica, finding that elemental compositions and environmental factors shape distinct microbial groups.

Disabling Cas9 by an anti-CRISPR DNA mimic

This study shows that AcrIIA4 inhibits Cas9 by binding to Cas9-sgRNA complexes, reducing off-target edits while allowing on-target gene editing in human cells.