Author

J. Sticht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Freund· 4 shared B. Kuropka· 2 shared B. Schraven· 1 shared C. Clementi· 1 shared C. Legrand· 1 shared C. Mix· 1 shared C. Wuelfing· 1 shared E. Dimou· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

C. Freund

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Author profile →

4 papers

Recent·Most cited

Quantitative analysis of MHC class II peptide exchange reveals pivotal role of peptide association rate

M. Günther, J. Sticht, C. Freund, T. Höfer

The paper develops a kinetic model to explain variation in HLA-DM susceptibility of MHC-II peptides and identifies two mechanisms shaping antigen presentation.

bioRxiv · Feb 12, 2024 · PreprintSystems Biology

Decoding of T cell immunodominance patterns by an integrated mechanistic approach

M. Alvaro-Benito, E. T. Abualrous, H. Lingel, S. Meltendorf, J. Holzapfel, P. de Diego Valera, J. Sticht, B. Kuropka, C. Clementi, F. Kuppler, M. C. Brunner-Weinzierl, C. Freund

The paper identifies immunodominant CD4+ T cell epitopes for SARS-CoV-2 antigens by integrating antigen processing systems with in silico tools, revealing distinct processing mechanisms for different antigens.

bioRxiv · Jan 10, 2024 · PreprintImmunology

ADAPs intrinsically disordered region is an actin sponge regulating T cell motility

N. Dadwal, J. Degen, J. Sticht, T. Hilal, T. Wegner, P. Reichardt, R. Lyck, M. Hons, M. Abadier, C. Mix, B. Kuropka, H. Stephanowitz, F. Liu, B. Schraven, C. Wuelfing, , C. Freund

This study identifies ADAP's intrinsically disordered region as an actin sponge that regulates T cell motility by promoting actin polymerization and bundling.

bioRxiv · Dec 14, 2021 · PreprintBiochemistry

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells

C. Legrand, R. Saleppico, J. Sticht, F. Lolicato, H.-M. Mueller, S. Wegehingel, E. Dimou, J. P. Steringer, H. Ewers, I. Vattulainen, C. Freund, W. Nickel

This study identifies a direct interaction between FGF2 and the Na,K-ATPase α1 subunit, showing it facilitates FGF2 membrane translocation upstream of PI(4,5)P2.

bioRxiv · Nov 1, 2019Biochemistry