F. Liu

Identifying Artifacts from Large Library Docking

The paper identifies docking artifacts in large library screens by rescoring top-ranked molecules with orthogonal methods, finding that 39 predicted cheaters failed experimental testing while 57% of plausible actives showed inhibition.

Identifying foraging spatial cues in beehive sound activity using machine learning methods

The paper uses machine learning to identify foraging spatial cues in beehive sound activity by analyzing Mel Frequency Cepstral Coefficients from recordings at different distances.

The impact of Library Size and Scale of Testing on Virtual Screening

This paper tests the impact of library size and testing scale on virtual screening by comparing results from 1.7 billion vs. 99 million molecule libraries against AmpC β-lactamase, finding improved hit rates and potency with larger libraries.

Innate immune system signaling and CD11b+CD11c+CD103+ cell migration to the brain underlie changes in mouse behavior after microbial colonization.

This study identifies innate immune signaling and CD11b+CD11c+CD103+ cell migration to the brain as mechanisms linking microbial colonization to behavioral changes in mice.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Unveiling the Secrets of Extracellular Vesicles in Urban Water Systems: Understanding the Link Between Human and Environmental Health

This study investigates extracellular vesicles in urban water systems to link human activities with microbial community impacts on public health and river biodiversity.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Colorectal ALOX15 as a host factor determinant of EPA and DHA effects on colorectal carcinogenesis

This study shows that ALOX15 expression modulates EPA and DHA effects on colorectal carcinogenesis by promoting resolvin generation, which suppresses pro-tumorigenic inflammation.

Detection of High-Frequency Oscillations from Intracranial EEG Data with Switching State Space Model

This paper uses a Switching State Space Model to automatically detect high-frequency oscillations in intracranial EEG data, improving accuracy compared to manual annotation.

Recombinant expression, purification, and antifungal activity of the novel antimicrobial peptide TaW662

This study identifies and characterizes TaW662, an antifungal peptide from wheat, showing inhibition of Blumeria graminis f. sp. tritici growth and potential as a fungicide.

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

Electrophysiological Brain Network Estimation with Simultaneous Scalp EEG and Intracranial EEG: Inference Algorithm and Applications

This paper introduces a framework integrating scalp EEG and intracranial EEG to estimate whole-brain electrophysiological networks using a state-space model and EM algorithm, showing improved performance over methods using only scalp EEG.

Molecular architecture of synaptic vesicles.

This study uses cryo-electron tomography to describe the molecular architecture and structural heterogeneity of individual synaptic vesicles in mouse brains and cultured neurons.

Engineering One-Signal Activated TILs with CD3ζ-CD28 Chimeras Optimizes the Antitumor Efficacy of TIL-Based Immunotherapy

This paper engineers one-signal-activated TILs with CD3ζ-CD28 chimeras to enhance antitumor efficacy in immunotherapy.

The impact of Arctic environments on human cerebral blood flow

This study examines changes in cerebral blood flow in Arctic conditions and finds reduced velocity and increased pulsatility in specific arteries.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

High-dimensional mass cytometry reveals stemness state heterogeneity in pancreatic ductal adenocarcinoma

The paper uses mass cytometry to analyze stemness states in PDAC, revealing molecular heterogeneity and identifying a subset with plastic phenotypes.

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Engineered Skin Microbiome Reduces Mosquito Attraction to Mice

This study reduces mosquito attraction to mice by engineering their skin microbiome to lower lactic acid production, offering longer protection than DEET.

The activated plant NRC4 immune receptor forms a hexameric resistosome

The study determines the cryo-EM structure of the auto-active NRC4 resistosome, revealing a hexameric configuration that triggers immune responses via cytosolic Ca2+ influx.

Structural Host-Virus Interactome Profiling of Intact Infected Cells

This study introduces SHVIP, a method to identify virus-host PPIs in intact infected cells, revealing 739 PPIs and validating their biological relevance through disruption experiments.

Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

This paper introduces a trizonal model to predict cancer cell shape transitions under ECM stiffening, revealing three motility zones and their implications for invasion.

Pan-genome analysis of different morphotypes reveals genomic basis of Brassica oleracea domestication and differential organogenesis

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.