Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma
E. F. Simonds, E. D. Lu, E. V. Liu, W. Tamaki, C. Rancan, J. Stultz, M. Sinha, L. K. McHenry, N. M. Nasholm, P. Chuntova, A. Sundstrom, V. Genoud, S. A. Shahani, L. D. Wang, c. brown, , M. Hellstrom
This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.
bioRxiv · Dec 1, 2020Cancer Biology