L. D. Wang

The 3D chromatin landscape of rhabdomyosarcoma

This study maps the 3D chromatin structure of rhabdomyosarcoma subtypes using Hi-C, revealing structural variations and gene regulatory patterns.

Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-Stimulation

This study compares IL13-ligand CAR designs to determine how co-stimulation domains affect tumor selectivity and anti-tumor activity against glioblastoma.

Deep Proteome Profiling of Human Mammary Epithelia at Lineage and Age Resolution

The paper profiles the proteome of human mammary epithelia across age and lineage, identifying age-related protein changes and potential therapeutic targets for breast cancer.

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

Arhgap25 deficiency leads to decreased numbers of peripheral blood B cells and defective germinal center reactions

This study shows that Arhgap25 deficiency in mice reduces peripheral B cell numbers and impairs germinal center formation and IgG1 class switching.

State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Leukemia Development

The paper models leukemia transcriptome dynamics in a state-space to identify critical points that predict disease development.