Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells
S. Pickering, J. Sumner, C. Kerridge, S. J. Neil
This study shows HIV-1 Vpu inhibits both canonical and non-canonical NF-κB pathways by differentially targeting β-TrCP1 and β-TrCP2, affecting immune responses and antiviral defenses in infected cells.
bioRxiv · Nov 30, 2022 · PreprintMicrobiology