Author

S. Pickering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:metagenomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. Winstone· 4 shared C. M. Swanson· 3 shared A. Dyer· 2 shared A. H. Patel· 2 shared G. De Lorenzo· 2 shared G. Nebbia· 2 shared H. Wilson· 2 shared K. J. Doores· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersMicrobiology

H. Winstone

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells

S. Pickering, J. Sumner, C. Kerridge, S. J. Neil

This study shows HIV-1 Vpu inhibits both canonical and non-canonical NF-κB pathways by differentially targeting β-TrCP1 and β-TrCP2, affecting immune responses and antiviral defenses in infected cells.

bioRxiv · Nov 30, 2022 · PreprintMicrobiology

The P681H mutation in the Spike glycoprotein escapes IFITM restriction and is necessary for type I interferon resistance in the SARS-CoV-2 alpha variant

M. J. Lista, H. Winstone, H. Wilson, A. Dyer, S. Pickering, R. P. Galao, G. De Lorenzo, V. Cowton, W. Furnon, N. M. Suarez, R. Orton, M. Palmirini, A. H. Patel, L. B. Snell, G. Nebbia, , S. J. Neil

This paper shows the P681H mutation in the SARS-CoV-2 alpha variant's Spike protein enables resistance to type I interferon and IFITM proteins, enhancing viral entry and transmission.

bioRxiv · Aug 11, 2022Microbiology

Disrupted Peyer's patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus

S. C. Trevelin, S. Pickering, K. Todd, C. Bishop, M. Pitcher, J. G. Mesa, L. Montorsi, F. Spada, N. Petrov, A. Green, M. Shankar-Hari, S. J. D. Neil, J. Spencer

This study examines the impact of COVID-19 on ileal Peyer's patches, finding disrupted microanatomy and germinal centre atrophy independent of local viral load.

bioRxiv · Dec 17, 2021Immunology

The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variant

M. J. Lista, H. Winstone, H. Wilson, A. Dyer, S. Pickering, R. P. Galao, G. De Lorenzo, V. Cowton, W. Furnon, N. M. Suarez, R. Orton, M. Palmarini, A. H. Patel, L. B. Snell, G. Nebbia, , S. Neil

This study shows the P681H mutation in the SARS-CoV-2 alpha variant's Spike protein confers resistance to Type I interferon, enhancing viral replication by evading innate immune responses.

bioRxiv · Nov 9, 2021 · PreprintMicrobiology

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

C. Graham, J. Seow, I. Huettner, H. Khan, N. Kouphou, S. Acors, H. Winstone, S. Pickering, R. Pedro Galao, M. Jose Lista, J. M. Jimenez-Guardeno, A. G. Laing, Y. Wu, M. Joseph, L. Muir, , K. J. Doores

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

bioRxiv · Feb 3, 2021 · PreprintImmunology

The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I IFN and IFITM2

H. Winstone, M. J. Lista Brotos, A. Reid, S. Pickering, K. J. Doores, C. M. Swanson, S. Neil

This paper shows that the polybasic cleavage site in SARS-CoV-2 spike protein reduces sensitivity to IFITM2 and type I IFNs, enhancing viral replication and transmission.

bioRxiv · Dec 19, 2020Immunology