S. Qian

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

Rim4 is a Meiotic Thermal Sensor and Drives Biogenesis of Stress Granules

This paper identifies Rim4 as a meiotic thermal sensor that forms reversible condensates triggered by heat, promoting stress granule assembly and protecting meiotic processes from thermal stress.

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

Cdc14 spatiotemporally regulates Rim4-mRNA complex assembly and stability during meiosis

This study identifies Cdc14's role in regulating Rim4-mRNA complex assembly and stability during meiosis through phosphorylation and spatial dynamics.

Autophagy inspects Rim4-mRNA interaction to safeguard programmed meiotic translation

The paper shows autophagy selectively degrades Rim4 during meiosis, sparing bound mRNAs for programmed translation.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

A Purinergic Mechanism Underlying Metformin Regulation of Hyperglycemia

The paper shows metformin reduces high glucose-stimulated ATP secretion, blocking purinergic signaling that causes hepatic insulin resistance and glucose production.

DENSS-Multiple: A Structure Reconstruction Method using Multiple Contrast Variation of Small-Angle Neutron Scattering Based on the DENSS Algorithm

DENSS-Multiple improves ab initio structure reconstruction using multiple SANS contrast variations to extract more information from contrast variation data.

The P2Y2 Nucleotide Receptor Mediates Monocyte Tissue Factor Expression and Endotoxemia Death in Mice

This study shows that the P2Y2 receptor in monocytes increases tissue factor expression, contributing to endotoxemia death in mice, and suggests it as a potential drug target.

Cdc14 activates autophagy to regulate spindle pole body dynamics during meiosis

This study identifies Cdc14 as a meiosis-specific autophagy regulator that controls spindle pole body dynamics by dephosphorylating Atg13 and promoting autophagy during anaphase I and II.

Super-dosed butyrate induces a revisable metabolic paralysis through transient mitochondrial reprogramming in the gut-brain axis

This study shows that high-dose sodium butyrate causes reversible metabolic paralysis by inducing transient mitochondrial reprogramming in the brain, specifically through ANT protein activation and proton leak.

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses