Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics
W. Mitchell, J. Tamucci, E. Ng, S. Liu, H. H. Szeto, E. R. May, A. Alexandrescu, N. N. Alder
This study analyzes structure-activity relationships of mitochondria-targeted tetrapeptides, finding that side chain composition and sequence register significantly affect their efficacy and membrane interactions.
bioRxiv · Nov 8, 2021 · PreprintBiochemistry