Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties
S. Boeynaems, A. S. Holehouse, V. Weinhardt, D. Kovacs, J. Van Lindt, C. Larabell, L. Van Den Bosch, R. Das, P. Tompa, R. V. Pappu, A. Gitler
This study shows that spontaneous interactions between proteins and RNA can form multi-layered condensates with distinct material properties and specific amino acid and RNA sequence dependencies.
bioRxiv · Dec 11, 2018Biophysics