P. Tompa

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensates

The paper identifies oncogenic fusion proteins that drive cancer by forming ectopic condensates that dysregulate transcription.

Menin regulates androgen receptor- and MLL-driven condensation, upsetting regulation of cellular AR-driven transcription.

This study shows menin regulates AR and MLL-driven RNA condensates through dimerization, affecting transcription regulation and contributing to cancer when disrupted.

Quantification of surface tension effects and nucleation-and-growth rates during self-assembly of biological condensates

The paper derives a kinetic solution to predict biological condensate formation by considering surface tension and nucleation-growth rates, showing large condensates can form without size control mechanisms.

MIADE metadata guidelines: Minimum Information About a Disorder Experiment

The paper introduces MIADE guidelines to standardize metadata for experiments studying intrinsically disordered proteins, improving data interpretation and reproducibility.

A pilot study of assisting IVF by personalized Endo-Gym exercises

This paper presents a pilot study showing that personalized Endo-Gym exercises can improve IVF success by addressing physical, psychological, and hormonal factors in women undergoing treatment.

WT and A53T α-synuclein systems: Melting Diagram and its new interpretation

The paper examines the thermodynamic properties of hydration water around wild-type and A53T α-synuclein monomers, oligomers, and amyloids, revealing structural disorder and hydration differences.

Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties

This study shows that spontaneous interactions between proteins and RNA can form multi-layered condensates with distinct material properties and specific amino acid and RNA sequence dependencies.