Author

J. Vuorio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Jacquemet· 2 shared I. Vattulainen· 2 shared J. Ivaska· 2 shared J. Lilja· 2 shared A. Isomursu· 1 shared A. K. Najumudeen· 1 shared D. Abankwa· 1 shared E. Kremneva· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

G. Jacquemet

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Author profile →

2 papers

Recent·Most cited

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

J. Lilja, J. Kaivola, J. R. W. Conway, J. Vuorio, H. Parkkola, P. Roivas, T. Varila, G. Jacquemet, E. Peuhu, E. Wang, U. Pentikäinen, I. M. D. Posada, H. Hamidi, A. K. Najumudeen, O. J. Sansom, , J. Ivaska

This study identifies SHANK3 as a RAS interactor that limits oncogenic KRAS signaling, and shows that disrupting its interaction with KRAS induces cell death in KRAS-mutant cancers.

bioRxiv · Sep 21, 2022 · PreprintCancer Biology

Conformational dynamics regulate SHANK3 actin and Rap1 binding

S. I. Salomaa, M. Miihkinen, E. Kremneva, I. Paatero, J. Lilja, G. Jacquemet, J. Vuorio, L. Antenucci, F. Hassani-Nia, P. Hollos, A. Isomursu, I. Vattulainen, E. T. Coffey, H.-J. Kreienkamp, P. Lappalainen, J. Ivaska

This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.

bioRxiv · Nov 12, 2020 · PreprintCell Biology