E. Wang

CRISPR-inhibition screen for lncRNAs linked to melanoma growth and metastasis

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

Circadian rhythms mediate malaria transmission potential

The paper shows that mosquito salivary gland and sporozoite gene expression cycles with the day-night rhythm, affecting malaria transmission.

Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification

This study shows osteoblast-derived matrix vesicles (Ost-MVs) contribute to atherosclerotic calcification by being released into circulation and transported to plaques, where they exacerbate calcification through the Ras-Raf-ERK pathway.

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunction

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

Designed mosaic nanoparticles enhance cross-reactive immune responses in mice

The paper designs mosaic nanoparticles with SARS-like betacoronavirus RBDs to enhance cross-reactive immune responses in mice, finding that mosaic-7COM elicits stronger responses against zoonotic sarbecoviruses and Omicrons.

Single-Cell RNA-seq based elucidation of the antidepressant hyperforin biosynthesis de novo in St. John's wort.

The paper identifies Hyper cells in St. John's wort where hyperforin biosynthesis occurs de novo and characterizes four prenyltransferases involved in its synthesis.

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

Comparative Phylogenomics and Phylotranscriptomics Provide Insights into the Genetic Complexity of Nitrogen Fixing Root Nodule Symbiosis

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood vaccination profiles.

This study maps human CD4+ T cell responses to Bordetella pertussis across its genome, revealing broad reactivity and similar polarization regardless of vaccination history.

Hybrid immunity elicits potent cross-variant ADCC against SARS-CoV-2 through a combination of anti-S1 and S2 antibodies

This study shows that hybrid immunity, from prior infection followed by vaccination, generates stronger and broader antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 variants than vaccination alone.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

This study identifies SHANK3 as a RAS interactor that limits oncogenic KRAS signaling, and shows that disrupting its interaction with KRAS induces cell death in KRAS-mutant cancers.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

Global quantitative understanding of nonequilibrium cell fate decision making in response to pheromone

This study quantitatively maps yeast cell fate decisions in response to pheromone by integrating experimental observations with theoretical models and stochastic simulations.

Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period

The paper assesses immunological memory to Common Cold Coronaviruses over three years and finds sustained CD4+ T cell and antibody responses, suggesting stable memory rather than frequent reinfections.

Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants

This paper designs SARS-CoV-2 variant antigens using sequence analysis and machine learning, showing they are stable and bind ACE2, and suggests a pan-coronavirus vaccine target.

Distinguishing COVID-19 infection and vaccination history by T cell reactivity

This study develops a T cell-based method to distinguish between SARS-CoV-2 infection and vaccination by analyzing T cell reactivity to specific epitopes, achieving high classification accuracy across different groups.

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

The paper develops a deep learning model to predict CRISPR-Cas13d guide RNA efficiency and identifies novel orthologs with improved specificity and reduced toxicity for RNA targeting.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration.

This study shows that influenza viral fusion peptides aggregate on membranes, altering structure and hydration to promote poration.

Tensin3 interaction with talin drives formationof fibronectin-associated fibrillar adhesions

This study identifies tensin3's interaction with talin as essential for fibronectin fibrillogenesis and integrin-associated fibrillar adhesions.

Phenotypic and Kinetic Changes of Myeloid Lineage Cells in Innate Response to Chikungunya Infection in Cynomolgus Macaques

This study examines kinetic and phenotypic changes in myeloid lineage cells during early Chikungunya infection in cynomolgus macaques, revealing altered cell turnover and activation states.

ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

This study identifies ADNKA as a mechanism by which SARS-CoV-2-infected cells evade NK cell inhibition, showing that non-spike antibodies drive sustained NK activation and cytokine production.

Genomic landscape of tumor-host interactions with differential prognostic and predictive connotations

The paper analyzes tumor-host interactions across 31 cancer types using the ICR signature to identify prognostic and predictive implications of immune phenotypes.

Germline genomic patterns are associated with cancer risk, oncogenic pathways and clinical outcomes

This study identifies seven germline genomic patterns associated with cancer risk, oncogenic pathways, and clinical outcomes across 22 cancer types.

Influence of Organic Matrix and Cations on Bio-Methane Yield with Anthracite Methanogenic Consortium

The paper investigates how organic matrix and cation concentrations affect bio-methane yield using an anthracite methanogenic consortium, finding optimal cation levels and the inhibitory effect of Mg2+.

Germline genetic variants associated with leukocyte-genes predict tumor recurrence in breast cancer patients

The paper uses germline genetic variants from exome sequencing data to predict tumor recurrence in ER+ breast cancer patients, finding gene signatures associated with recurrence and immune-related pathways.

Primary Studies on the Effect of Microbially Coalbed Methane Enhancement in Suit in the Qinshui Basin

The paper investigates the effectiveness of microbial coalbed methane enhancement in the Qinshui Basin, showing increased methane production through biogasification in specific wells.