H. Hamidi

Constitutive protein degradation induces acute cell death via proteolysis products

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

This study identifies SHANK3 as a RAS interactor that limits oncogenic KRAS signaling, and shows that disrupting its interaction with KRAS induces cell death in KRAS-mutant cancers.

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

Signatures of Mutational Processes in Human DNA Evolution

The paper identifies four mutational processes responsible for human genetic variations, with three active in all populations and one specific to mitochondrial DNA.

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels

This study investigates how fibrillar adhesions respond to mechanical cues by using stiffness-gradient gels and identifies tensin-dependent growth of these structures in response to stiffness.

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

This study identifies GGA2 and RAB13 as regulators of activity-dependent β1-integrin recycling, showing their roles in maintaining integrin activity and cell migration.

Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability

The paper maps filopodia adhesions using structured illumination microscopy and identifies p130Cas as a mechanosensitive regulator of filopodia stability.

FiloQuant reveals increased filopodia density during DCIS progression

FiloQuant quantifies filopodia density and dynamics in various cell types and microenvironments, revealing increased filopodia density during DCIS progression.