Transcription Factor NRF2 is Activated by Erythrophagocytosis of Oxidized Red Blood Cell Products and Suppresses the IL-12-IFNg-IL-10 Axis in a Murine Model of Hyperinflammatory Disease
P. M. Gallo, E. Elliott, G. Ford, C. Biswas, J. Kim, J. Wheaton, C. Jiang, N. Chu, P. A. Kreiger, M. P. Lambert, E. M. Behrens
This study shows that NRF2 activation by erythrophagocytosis suppresses the IL-12-IFNg-IL-10 axis, reducing hyperinflammation in a murine model of hyperinflammatory disease.
bioRxiv · Dec 12, 2023 · PreprintImmunology