ImmunologybioRxivPreprint
Transcription Factor NRF2 is Activated by Erythrophagocytosis of Oxidized Red Blood Cell Products and Suppresses the IL-12-IFNg-IL-10 Axis in a Murine Model of Hyperinflammatory Disease
P. M. Gallo, E. Elliott, G. Ford…·E. M. Behrens
This study shows that NRF2 activation by erythrophagocytosis suppresses the IL-12-IFNg-IL-10 axis, reducing hyperinflammation in a murine model of hyperinflammatory disease.
DOI 10.1101/2023.12.12.571271