Ligand-directed covalent labelling of a GPCR with a fluorescent tag
L. A. Stoddart, N. D. Kindon, O. Otun, C. R. Harwood, F. Patera, D. B. Veprintsev, J. Woolard, S. J. Briddon, H. A. Franks, S. J. Hill, B. Kellam
The paper describes a compound that covalently labels a GPCR with a fluorescent tag without blocking its binding site, enabling study of native GPCR function and localization.
bioRxiv · Apr 21, 2020Pharmacology & Toxicology