Author

B. Kellam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

S. J. Briddon· 3 shared J. Woolard· 2 shared C. R. Harwood· 1 shared D. A. Briggs· 1 shared D. B. Veprintsev· 1 shared F. Patera· 1 shared H. A. Franks· 1 shared H. A. Mbiwan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPharmacology & Toxicology

S. J. Briddon

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A time-resolved Forster resonance energy transfer assay to investigate inhibitor binding to ABCG2

J. I. Mitchell-White, D. A. Briggs, S. J. Mistry, H. A. Mbiwan, B. Kellam, N. D. Holliday, S. J. Briddon, I. D. Kerr

The paper introduces a TR-FRET assay to measure inhibitor binding to ABCG2 and confirms NBD dimerization correlates with a shift in inhibitor affinity.

bioRxiv · Oct 27, 2023 · PreprintBiochemistry

Ligand-directed covalent labelling of a GPCR with a fluorescent tag

L. A. Stoddart, N. D. Kindon, O. Otun, C. R. Harwood, F. Patera, D. B. Veprintsev, J. Woolard, S. J. Briddon, H. A. Franks, S. J. Hill, B. Kellam

The paper describes a compound that covalently labels a GPCR with a fluorescent tag without blocking its binding site, enabling study of native GPCR function and localization.

bioRxiv · Apr 21, 2020Pharmacology & Toxicology

Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies

M. Soave, R. Heukers, B. Kellam, J. Woolard, M. J. Smit, S. J. Briddon, S. Hill

The paper uses nanobodies conjugated with NanoBiT to monitor ligand-induced conformational changes in the CXCR4 receptor.

bioRxiv · Apr 21, 2020 · PreprintPharmacology & Toxicology