Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies
E. M. Struijf, K. I. De la O Becerra, M. Ruyken…·S. H. M. Rooijakkers
This study identifies and characterizes two high-affinity anti-C5 nanobodies that inhibit C5 cleavage and recognize distinct epitopes, including a variant not targeted by Eculizumab.