Author

M. Soave

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Inoue· 1 shared A. Jazayeri· 1 shared A. Politis· 1 shared B. Al-Zaid· 1 shared B. Kellam· 1 shared D. I. Mackie· 1 shared D. R. Poyner· 1 shared D. Safitri· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. Inoue

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

J. Toporowska, P. Kapoor, M. Musgaard, K. Gherbi, K. Sengmany, F. Qu, M. Soave, H.-Y. Yen, K. Hansen, A. Jazayeri, J. T. S. Hopper, A. Politis

This study uses HDX-MS to analyze structural dynamics of tβ1AR with different ligands, revealing ICL1 dynamics linked to GPCR activation and drug modality.

bioRxiv · Feb 7, 2024Biophysics

RAMPs regulate signalling bias and internalisation of the GIPR

M. Harris, D. I. Mackie, J. B. Pawlak, S. Carvalho, T. T. truong, D. Safitri, H. Y. Yeung, S. Routledge, M. T. Harper, B. Al-Zaid, M. Soave, S. Al-Sabah, A. Inoue, D. R. Poyner, S. J. Hill, , G. Ladds

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

bioRxiv · Apr 8, 2021 · PreprintPharmacology & Toxicology

Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies

M. Soave, R. Heukers, B. Kellam, J. Woolard, M. J. Smit, S. J. Briddon, S. Hill

The paper uses nanobodies conjugated with NanoBiT to monitor ligand-induced conformational changes in the CXCR4 receptor.

bioRxiv · Apr 21, 2020 · PreprintPharmacology & Toxicology