Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir
H. S. Lo, K. P. Y. Hui, H.-M. Lai…·W.-L. Ng
The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.
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4 papers
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H. S. Lo, K. P. Y. Hui, H.-M. Lai…·W.-L. Ng
The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.
A. Shannon, V. Fattorini, B. Sama…·B. Canard
This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.
C. Eydoux, V. Fattorini, A. Shannon…·J.-C. Guillemot
The paper describes a fluorescence-based high-throughput screening assay for identifying inhibitors of the SARS-CoV RNA synthesis complex using a purified and active replication/transcription complex.