Author

J.-K. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

E. D. Handly· 2 shared M. B. Yaffe· 2 shared A. C. Palmer· 1 shared A. Dinh· 1 shared A. Izrael-Tomasevic· 1 shared A. M. Hosios· 1 shared C. M. Rose· 1 shared D. J. Irvine· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

E. D. Handly

Mutual co-authors in cluster

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2 papers

Recent·Most cited

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

J.-K. Chen, K. A. Merrick, Y. W. Kong, A. Izrael-Tomasevic, G. Eng, E. D. Handly, J. C. Patterson, L. Suarez-Lopez, A. M. Hosios, A. Dinh, D. S. Kirkpatrick, K. Yu, C. M. Rose, J. M. Hernandez, H. Hwangbo, , M. B. Yaffe

This paper shows 5-FU's lethality in tumors is due to an RNA damage response, not DNA damage, and that targeting this response could improve cancer therapy.

bioRxiv · Apr 28, 2023 · PreprintCancer Biology

The Injury Response to DNA Damage Promotes Anti-Tumor Immunity

G. Sriram, L. E. Milling, J.-K. Chen, W. Abraham, E. D. Handly, D. J. Irvine, M. B. Yaffe

This study shows that ex vivo DNA-damaged tumor cells as an adjuvant enhance anti-tumor immunity when combined with immune checkpoint inhibitors, requiring live injured cells and specific signaling pathways.

bioRxiv · Apr 26, 2020 · PreprintCancer Biology