K. Yu

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

A neurovascular progenitor sits at the nexus of glioblastoma lineage trajectories

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

This study identifies MMP1+ fibroblasts as a cellular determinant of resistance to PD-1 pathway blockade in NSCLC by analyzing single-cell RNA sequencing data and spatial architecture.

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

The paper identifies IL-1β as a factor that inhibits SARS-CoV-2-induced cell-cell fusion by promoting actin bundles, thereby restricting viral transmission.

The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation

The paper identifies USP12/46 deubiquitinases that prevent ESCRT-mediated lysosomal degradation of β1 integrin by removing ubiquitin from its cytoplasmic tail in early endosomes.

Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased degradation of cell surface proteins

The maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehavioral impairment in mice

This study shows that maternal microbiome alterations during protein undernutrition in mice modify offspring neurobehavioral impairments, with microbiome-targeted interventions offering potential mitigation.

Disease resistance of Brassica juncea to Sclerotinia sclerotiorum is established through the induction of indole glucosinolate biosynthesis

The paper identifies a resistant Brassica juncea line H83 and reveals a novel regulatory network involving indole glucosinolate biosynthesis in response to Sclerotinia sclerotiorum infection.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Forest demography and biomass accumulation rates are associated with transient mean tree size vs density scaling relations

The paper links mean tree size and density scaling relationships to biomass accumulation rates and demographic processes across forest biomes.

Nitrite deteriorates bioreactor performance by reducing growth of Ca. Brocadia sapporoensis instead of inhibiting the anammox activity

This study shows that nitrite reduces the growth of Ca. Brocadia sapporoensis in anammox systems, leading to performance collapse, rather than directly inhibiting anammox activity.

Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids

The paper shows that IncX4 plasmids with pir-1 have higher mcr-1 expression and fitness burden but lower invasion rates compared to pir-2 plasmids, explaining why mcr-1 is absent from pir-2 plasmids.

Metagenomic Analysis Reveals the Transfer of Antibiotic Resistance from Manure-Fertilized Soil to Carrot Microbiome

The paper investigates the transfer of antibiotic resistance genes from manure-fertilized soil to carrot microbiomes, finding that beta-lactamases are transferred via rhizosphere microbes despite limited plasmid-mediated resistance.

Niclosamide potentiates TMEM16A and induces vasoconstriction

This study shows niclosamide potentiates TMEM16A and induces vasoconstriction, challenging its use as a TMEM16A inhibitor for asthma and COPD.

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

This study shows that truncating the C-terminus of CXCL10 reduces its inflammatory activity but maintains its anti-angiogenic effects.

Unravelling Biosynthesis and Biodegradation Potentials of Microbial Dark Matters in Hypersaline Lakes

This study identifies novel biosynthesis and biodegradation potentials in microbial dark matter from hypersaline lakes, expanding genetic resources for biotechnology.

Multi temporal multispectral UAV remote sensing allows for yield assessment across European wheat varieties already in tillering stage

This study uses multispectral UAV data to predict wheat yield potential across varieties during the tillering stage, finding visible bands outperform Red-edge bands for early yield assessment.

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

This paper shows 5-FU's lethality in tumors is due to an RNA damage response, not DNA damage, and that targeting this response could improve cancer therapy.

Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes

This study uses computational drug repositioning to identify agents that can sensitize drug-resistant breast tumors, finding fulvestrant effective across multiple treatment and receptor subtypes.

Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities

The paper develops and characterizes new osteosarcoma PDX models with varying metastatic capacities to study disease biology and test therapeutic interventions.

Expanding the diversity of Accumulibacter with a novel type and deciphering the transcriptional and morphological features among co-occurring strains

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

Low-intensity transcranial focused ultrasound suppresses pain by modulating pain processing brain circuits

This paper demonstrates that low-intensity transcranial focused ultrasound can suppress pain by modulating pain processing brain circuits in mouse models.

Cassava Detection from UAV Images Using YOLOv5 Object Detection Model: Towards Weed Control in a Cassava Farm

This paper evaluates YOLOv5n and YOLOv5s models for cassava detection in UAV images, finding trade-offs between speed and accuracy under varying field conditions.

Characterization of N distribution in different organs of winter wheat using UAV-based remote sensing

This study evaluates UAV-based remote sensing for predicting nitrogen content and nitrogen agronomic efficiency in winter wheat organs using vegetation indices and texture features.

Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors

The gut bacterium Eggerthella lenta secretes inhibitors of P-glycoprotein ATPase activity, accelerating drug absorption.

Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales

This study investigates how glioblastoma disrupts cortical network activity, showing increased neural hyperexcitability and abnormal glutamate accumulation during tumor progression.

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

Directional selection at gene expression level contributes to the speciation of Asian rice cultivars

The paper identifies directional selection at the gene expression level contributing to phenotypic differences between indica and japonica rice subspecies.

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.