PathologybioRxiv
Host prion protein expression levels impact prion tropism for the spleen
V. Beringue, P. TIXADOR, O. ANDREOLETTI…·H. LAUDE
This study shows that prion substrain tropism for the spleen is influenced by PrPC expression levels, with low-expressing substrains dominating in the spleen while high-expressing substrains struggle to replicate there.