Molecular elucidation of drug-induced abnormal assemblies of the Hepatitis B Virus capsid protein by solid-state NMR
L. Lecoq, L. Brigandat, R. Huber, M.-L. Fogeron, M. Callon, A. Malaer, S. Wang, M. Dujardin, M. Briday, T. Wiegand, D. Durantel, D. Burdette, J.-M. Berke, B. H. Meier, M. Nassal, A. Bockmann
This study uses solid-state NMR to elucidate the molecular structure of drug-induced aberrant HBV capsid assemblies and reveals differences in capsid-RNA interactions and phosphorylation between in-cell and in vitro conditions.
bioRxiv · Sep 14, 2022Biophysics