The nucleus acts as a ruler tailoring cell responses to spatial constraints
A. Lomakin, C. Cattin, D. Cuvelier, Z. Alraies, M. Molina, G. Nader, N. Srivastava, J.-M. Garcia Arcos, I. Zhitnyak, A. Bhargava, M. K. Driscoll, E. S. Welf, R. P. Fiolka, R. Petrie, N. Manel, , M. Piel
The paper shows that the nucleus acts as a ruler by triggering contractile responses when confined, influencing cell migration and processes like cancer invasion and immune responses.
bioRxiv · Dec 5, 2019Cell Biology