N. Manel

A gene silencing pipeline to interrogate human cDC1 and pDC development and functions

This paper develops a gene silencing pipeline to study human cDC1 and pDC development and functions, identifying key regulators and HIV-1 restriction factors.

A Shape Sensing Mechanism driven by Arp2/3 and cPLA2 licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

The paper identifies a shape sensing mechanism in dendritic cells that links cell motility to CCR7 expression, enabling migration to lymph nodes through ARP2/3-cPLA2 signaling.

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

The paper shows that loss of SAMHD1 leads to chronic DNA damage and cGAS/STING-dependent type I interferon production in mice, linking it to autoimmunity and cancer.

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

Cellular selectivity of STING stimulation determines priming of tumor-specific T cell responses

This study shows that targeting STING in dendritic cells with cGAMP-VLP enhances tumor-specific T cell responses and synergizes with PD1 blockade for tumor eradication, while synthetic CDN causes systemic T cell activation without specific T cell differentiation.

Induction of transposable element expression is central to innate sensing

The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

The paper identifies twenty-one host genes that modulate flavivirus replication in an interferon-dependent manner using siRNA screening in ZIKV-infected microglial cells.

Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics

This study shows SUN1 and SUN2 inhibit HIV-1 and HIV-2 infection through distinct mechanisms involving chromatin dynamics and DNA damage response.

Compromised nuclear envelope integrity drives tumor cell invasion

The paper shows that mechanical nuclear envelope ruptures in cancer cells cause DNA damage and promote invasion through ATM activation and TREX1 depletion.

The nucleus acts as a ruler tailoring cell responses to spatial constraints

The paper shows that the nucleus acts as a ruler by triggering contractile responses when confined, influencing cell migration and processes like cancer invasion and immune responses.

A comprehensive map of the dendritic cell transcriptional network engaged upon innate sensing of HIV

This study maps the transcriptional network in HIV-1 infected dendritic cells, identifying key regulators of interferon response and maturation.