R. P. Fiolka

The paper introduces a mesoscopic oblique plane microscope for whole-organism imaging with high speed and subcellular resolution, demonstrating its application in zebrafish vasculature and blood flow analysis.

This paper introduces OPSIM, a structured illumination microscopy technique that enables rapid whole-cell imaging with doubled resolution, achieving up to 2.7 Hz for mitochondrial and ER dynamics.

This paper demonstrates isotropic resolution doubling in light-sheet microscopy using oblique plane structured illumination, achieving sub-150nm lateral resolution with reduced phototoxicity and faster volumetric imaging.

This paper introduces a dual-axis scan unit for oblique plane microscopy to increase field-of-view and imaging speed, enabling high-resolution volumetric imaging of zebrafish embryos.

The paper shows that microtubules form a mechanostat to coordinate contractility and nuclear positioning during confined cell migration.

This study shows blebs form signaling hubs that promote anoikis resistance in cancer cells by recruiting septins and activating ERK/PI3K pathways.

This study shows that heterozygous Vegfr3 mutation reduces renal lymphatics but does not impair renal function or histology, even after cisplatin injury.

u-track 3D provides a software package for analyzing dense 3D particle dynamics in microscopy data by improving visualization, trajectory validation, and interactive exploration.

The paper shows amoeboid melanoma cells migrate through crowded environments by mechanically degrading extracellular matrix via bleb-driven abrading, without proteolysis.

This paper introduces a projection imaging method that enables real-time, multi-angle visualization of biological processes with reduced data overhead.

This paper introduces an improved oblique plane microscope with enhanced resolution and usability, demonstrating its application in imaging various subcellular dynamics and challenging biological phenomena.

This paper introduces an optical design that converts lateral scanning into axial focusing, enabling rapid, high-resolution 3D imaging with axially swept light-sheet microscopy.

The paper shows that the nucleus acts as a ruler by triggering contractile responses when confined, influencing cell migration and processes like cancer invasion and immune responses.

This paper proposes a simplified dual-objective structured illumination microscopy method to improve axial resolution without interferometric detection.

This paper introduces C-light-sheets, a method to continuously tune light-sheet thickness and illumination confinement using the Field Synthesis theorem for improved imaging.

This paper introduces Field Synthesis, a theorem that simplifies light-sheet generation for microscopy, enabling high-throughput, multicolor imaging with reduced photobleaching.