Cancer BiologybioRxiv
MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
C. M. Guerin, A. Vinchent, M. Fernandes…·D. Tulasne
This paper identifies N-lobe MET mutations in HPRCC that require ligand stimulation for activation, unlike kinase domain mutations, and shows their sensitivity to MET inhibitors.
DOI 10.1002/1878-0261.13806